ABSTRACT
Background: Angiogenic factors are set of growth factors that directly and indirectly enhances vessels in the tissue
On the other hand, seem to medicinal extract some herbs can interact with growth factor pathways
Objective: The aim of this study was to determine the effect of six weeks of progressive aerobic training and aqueous extract of Crataegus monogyna on VEGF variations and plasma angiopoetin-1/2 in male Wistar rats
Methods: 32 male Wistar rats, 4-6 months old, were randomly divided into four groups: control Crataegus monogyna, training Crataegus monogyna, control saline and training saline
A milli liter aqueous extract of Crataegus monogyna 100 g per body weight orally immediately after training, five days in a week for six weeks from the end of the second week was given to mice
Data were analyzed using one-way ANOVA at the significant level P<0.05
Results: the results showed that progressive endurance training reduced VEGF of plasma in the training group, Crataegus monogyna group and training-Crataegus monogyna group comparing the control group. Plasma ANG-1 concentration reduced in the training, Crataegus monogyna and training-Crataegus monogyna groups while plasma ANG-2 concentration significantly increased in the Crataegus monogyna group [P=0.022] comparing with the control group
The ratio of plasma ANG-2 to ANG-1 significantly increased in the Crataegus monogyna group [P=0.028] comparing with the control group
Conclusion: The findings suggest that combination of aerobic training and Crataegus monogyna extract has no synergistic effect on anti-angiogenesis indicators
ABSTRACT
Background and Aim: The aim of this study was to make a comparison between the effects of eight weeks aerobic and resistance training on paraoxonase-1, arylesterase activity and lip id profile in obese girls
Material and method: 30 obese women with mean values for age 30+/-5years, height 1.60+/-2m and weight 85.23+/-6.7kg, and body mass index of 31-33kg/m[2] were divided randomly into three aerobic exercise [n=10], resistance training [n=10] and control [n=10] groups. Experimental groups performed aerobic exercise on treadmill between 60 to 75% of heart rate reserve and resistance training between 55 to 75% 1RM for 8 weeks
Blood samples were taken from the subjects 48 hours before and 48 hours after training and also after 12 hours of fasting. Data were analyzed by use of ANOVA and Tukey post hoc test. P<0.05was considered significant
Results: The results showed that aerobic exercise had a significant effect on serum concentrations of paraoxonase-1 [PM3.001] and arylesterase [P=0.006] in obese girls
However, there was no significant difference between the effects of eight weeks of aerobic and resistance training on the plasma levels of cholesterol, triglycerides and LDL in obese girls [P<0.05]
Also, the results showed that plasma HDL levels significantly increased after eight weeks of aerobic training in obese girls [P=0.007]
The effects of eight weeks of aerobic and resistance training on plasma VLDL level, were significantly different from those of the control group [P=0.001]
Conclusion: According to the results of this study, it seems that aerobic exercise can increase paraoxonase-1 and arylesterase plasma levels and also modify lip id profile which can result in reduced risk of cardiovascular diseases in obese people